4SC assets available for out-licensing

More information on these assets are available under request.


4SC-205 is an anti-cancer compound that inhibits the kinesin spindle protein Eg5 (KIF11), which plays a key role in cell division and growth of tumor cells. Cell division inhibitors have been successful cancer therapies, however, they have serious side effects on the peripheral nervous system. Due to 4SC-205’s special mechanism of action, the compound does not cause such adverse side effects.

4SC-205 is the only orally administered Eg5 inhibitor currently in clinical development to the best of the Company’s knowledge. 4SC-205 is administered orally in low doses to maintain a steady bioavailability and exhibit continuous therapeutic effect. The anti-tumor efficacy of 4SC-205 was demonstrated in diverse pre-clinical models. In a Phase I clinical study (AEGIS) the drug demonstrated good safety and was well-tolerated; initial indications of efficacy were also determined.

4SC-205 is so far licensed for China, Hong Kong, Taiwan and Macao to Guangzhou Link Health Pharma Co., Ltd (Link Health).

AEGIS – First-in-human study of 4SC‑205 in solid tumors


The AEGIS study was a first-in-human, multi-center, open label, dose escalation Phase I first-in-human study of oral 4SC 205 in patients with advanced malignancies.

Recruitment status Completed
Study phase Phase I
Enrollment 60
Primary objectives
  • Safety and tolerability of repeated ascending oral doses
  • Maximum tolerated dose (MTD) and dose-limiting toxicities (DLT)
Secondary objectives
  • Assess anti-tumor activity after 6 weeks of treatment
Exploratory objectives
  • Assess effects of Eg5 inhibition on biomarker modulation

Poster presentations

30 May 2015
2015 Annual Meeting of the American Society of Clinical Oncology (ASCO)
Chicago, USA
Overcoming the proliferation rate paradox: Clinical evaluation of a continuous dosing scheme of the novel oral Eg5 inhibitor 4SC-205


1 June 2014
2014 Annual Meeting of the American Society of Clinical Oncology (ASCO)
Chicago, USA
First-in-human study of 4SC-205 (AEGIS), a novel oral inhibitor of Eg5 kinesin spindle protein


Kv1.3 Inhibitors

Kv1.3 is a voltage-gated ion channel which has diverse functions in various cell types and cellular mechanisms but plays an essential role in the activation and proliferation of T-cells. 4SC’s family of Kv1.3 ion channel inhibitors are designed to act on chronically stimulated cell populations whilst sparing “normal” immune cells, thus addressing an underlying pathogenic principle in a multitude of autoimmune diseases.

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