Acute Myeloid Leukaemia
Malignant form of cancer affecting part of the haemopoietic system.
Abbreviation for adverse events.
Abbreviation for available for sale, one of four categories of financial instruments.
Abbreviation for at fair value through profit or loss, one of four categories of financial instruments
Abbreviation for acute myeloid leukaemia.
Inhibiting mitosis, i.e. cell nucleus division.
The process of programmed cell death. This process can be caused by external factors, for example it may be triggered by immune cells, or may be activated due to cellular processes such as a damaged genome. Apoptosis is actively conducted by the cell´s internal components and results in destruction of the cell.
German abbreviation for the German Federal Ministry of Education and Research.
Compound Annual Growth Rate. The annualised growth rate of an investment over a specified period of time.
Trials (Phase I through III) in drug development that are conducted in healthy subjects and patients.
Abbreviation for colorectal cancer.
Directors & Officers insurance.
Concept of corporate governance, that takes into account the diversity of people and functions among a company's workforce, management and Supervisory Board.
DNA (Deoxyribonucleic acid)
Deoxyribonucleic acid is a biological molecule that contains the genetic information in a cell and codes the blueprint for making the proteins.
Abbreviation for duration of response.
Kinesin spindle protein which plays a role in the distribution of chromosomes to the daughter cells during cell division.
Abbreviation for epidermal growth factor receptor; a transmembrane receptor with intrinsic tyrosine kinase activity that is highly regulated and/ or found in mutated form in many types of tumours, thus leading to uncontrolled cell growth.
General result of a study that evaluates the outcome of the individual steps based on a clinical trial protocol.
Protein which enables or accelerates chemical reactions in cells by acting as a catalyst.
Method used in annual financial statements to account for an entity’s investment in another entity’s voting capital.
Abbreviation for employee stock option programme.
Abbreviation for “first in, first out”; a procedure related to the measurement of inventories and their utilisation in connection with fluctuating procurement prices.
Voluntary, usually healthy person participating in a clinical study.
Chemotherapy scheme for treating colon cancer.
Abbreviation for hepatocellular carcinoma.
Abbreviation for histone deacetylase.
Histone deacetylase inhibitor designed to prevent the cell division process of tumours directly and in a targeted way.
Malignant tumour triggered by the hepatocytes of the liver’s tissue; the most common form of liver cancer.
Abbreviation for Hodgkin’s lymphoma.
Hodgkin’s lymphoma is a malignant tumour in the lymph nodes.
Abbreviation for held to maturity, one of four categories of financial instruments.
Abbreviation for International Accounting Standards.
Abbreviation for International Accounting Standards Board.
Abbreviation for International Financial Reporting Interpretations Committee.
Abbreviation for International Financial Reporting Standards.
Annual test of recognised goodwill for impairment.
Description based on silicon, the chemical element used to manufacture computer chips. Computer-based simulation of biochemical processes and examination of the effi cacy of molecules.
Experiments that take place in a controlled, artificial environment outside of the living organism, e.g. in a test tube.
Experiments that take place in the living organism, e.g. in animal testing.
Substance that inhibits a specific enzyme reaction.
Abbreviation for international nonproprietary name, which is granted by the WHO.
Protein which controls cellular signal transfer.
Abbreviation for loans and receivables, one of four categories of financial instruments.
Medical Ethics Committee
Assessment of ethical and legal aspects of medical research in human beings; the medical ethics committee must approve the commencement of clinical studies
Abbreviation for objective overall response rate.
Abbreviation for overall survival.
Granting of a license to a third party to use one or more industrial property rights.
Abbreviation for progression free survival.
Abbreviation for progression free survival rate.
Study of the efficacy of drugs in a living organism.
Spatial and temporal distribution of compounds throughout the various tissues of an organism.
Clinical trial of a drug conducted in a small number of healthy patients subject to strict controls; serves to test the tolerance, pharmacokinetics, method of administration and safe dose of the compound.
Clinical trial conducted in a small number of patients subject to strict controls to identify a compound’s sudden side effects and risks; determination of the efficacy of the drug and any potential side effects.
Study conducted in a large number of patients (between several hundred and several thousand) to determine the safety, efficacy and optimum dosage of a drug under real therapeutic conditions.
Laboratory tests related to a new drug candidate conducted in animals, organs or cell cultures in order to obtain satisfactory evidence that a clinical study is justified and that the drug candidate is classified as safe.
Listing segment of Deutsche Börse with clearly defined transparency requirements.
Milestone proving a drug candidate’s efficacy in medical terms, usually in Phase II.
Multi-protein complex for the decomposition of used cellular products.
Large complex molecule composed of amino acids. Proteins are essential to the structure, regulation and function of all organisms; typical proteins include enzymes and antibodies.
Abbreviation for response evaluation criteria in solid tumours; guidelines on the evaluation of therapeutic success in solid tumours.
Compensation for the use of third-party rights to intellectual property. Royalties are generally calculated as a certain percentage of the revenue generated from the intellectual property rights.
Abbreviation for serious adverse events.
Abbreviation for Standing Interpretations Committee.
Class of hormones such as cholesterol which has an anti-inflammatory effect.
Specific biological molecule, e.g. an enzyme or receptor, which plays an important role in the origination or development of a disease. Compounds/drugs develop their therapeutic activity by binding to a target molecule.
Specific influencing and controlling of signalling pathways in cancer and autoimmune diseases.
Undesirable side effects of a substance depending on its dose.
Field of science examining the effects of toxic substances or the toxicity of substances.
Abbreviation for time to progression.
World Health Organization; the United Nations agency responsible for international public health.